Epigenetics in the Age of Twitter

  

256 pages

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ISBN: 9781934137390


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ISBN: 9781934137512




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“[Weissmann] has emerged in the last three decades as America’s most interesting and important essayist. He has achieved this status both epigenetically and through Twitter, word of mouth, so to speak. . . . Much like Susan Sontag, Weissmann likes being a contemporary, and does not feel shackled by tradition. . . . This book is a joy for the heart and instructive for the mind.”

Eric Kandel, Nobel Laureate and author of The Age of Insight

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“Erudite energy leaps from this lively commingling of art, culture and science. . . . In each [essay], Weissmann finds links between research and elements of history and pop culture, which play off each other to illuminating effect.”

Nature

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“Intertwine[s] the profound connections of science and art in the context of our modern era. . . . Weissmann also does a fantastic job of highlighting the role of women in both the arts and sciences. . . . Each essay provides its fair share of wit and satire, poignantly illustrating faults or curiosities in current scientific thought or public discourse of the scientific realm.”

Science

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“Only a mind as nimble and well traveled as Gerald Weissmann’s could see, never mind make and expound on, the connections between salamanders and Prohibition . . . white blood cells, Hollywood and erectile dysfunction . . . health care reform and Marie Antoinette . . . bacteria, the Equal Rights Amendment and the “Miracle on the Hudson.” Better yet, Weissmann does so with wit and insight. A fascinating tour through history, science and pop culture.”

Dr. Max Gomez, Emmy Award-winning WCBS-TV Medical Correspondent

Epigenetics, which attempts to explain how our genes respond to our environment, is the latest twist on the historic nature vs. nurture debate. In addressing this and other controversies in contemporary science, Gerald Weissmann taps what he calls “the social network of Western Civilization,” including the many neglected women of science: from the martyred Hypatia of Alexandria, the first woman scientist, to the Nobel laureates Marie Curie, Christiane Nüsslein-Volhard, and Elizabeth Blackburn, among other luminaries in the field. Always instructive and often hilarious, this is a one-volume introduction to modern biology, viewed through the lens of today’s mass media and the longer historical tradition of the Scientific Revolution. Whether engaging in the healthcare debate or imagining the future prose styling of the scientific research paper in the age of Twitter, Weissmann proves to be one of our most incisive cultural critics and satirists.

Excerpt from Epigenetics in the Age of Twitter

The essays in this book deal with modern science and the popular arts. There are, of course, real differences between art and science: in science if another lab replicates your work, you call to congratulate them; in the arts your lawyer calls. Another difference is that no real work of science has ever made anyone laugh out loud.

Arts and Sciences at one point did mean “Paintings and Stuff and Petri dishes and Stuff,” to quote Zadie Smith.(1) But in the age of Twitter, Facebook and Buzznet, arts and sciences follow YouTube’s charge to “Broadcast Yourself!” These days one click on Twitter separates Shawn Corey Carter (Jay-Z), a rapper who is CEO of Roc-A-Fella Records and who owns the NJ Nets, from Eric Kandel, our leading neuroscientist and who owns a Nobel Prize.(2) Walter Benjamin, the “popular wise guy”1 had it right: every reader has become a writer – or tweeter – in the age of electronic reproduction.

My essays play off one or another discovery of today’s biological science (with epigenetics leading the pack) against one or another aspectof popular culture: film, television, sports, etc. (with Twitter et al leading the pack.) We’ll see what the molecular biology of aging has to do with Sarah Palin’s hair, why a Nobel prize for reproductive biology clashed with J-Lo’s notion of fertility, and why the name on Oklahoma State’s football stadium (T. Boone Pickens) scuppered basic research on anthrax.

Twitter first. To learn what Twitter could do for me, I signed up a couple of years ago under the nom de silico “Franz Anton Mesmer,” (1734-1815) or franzmesmer@twitter.com. Sure enough, I soon had half a dozen “followers.” I told this to a psychiatrist friend of mine, who was astonished that anyone would follow the words of a dead hypnotist. I pointed out that this was the basis of organized religion, not to speak of Freudian analysis.

While Twitter is the latest effort of popular culture to see how little one can say to the largest audience, epigenetics is the latest twist on the historic nature/nurture debate in biology. Epigenetic changes are short-term heritable alterations in gene expression that are not due to mutations in DNA. An analogy: if DNA is a language composed of the letters A,T,G,C, epigenetic changes are like variations in a letter’s font, i.e. C to C, or its context, i.e. C to ©. We’ve pieced together some of the machinery that accomplishes this trick, but we’re still at sea as to how it all works.(3)

Darwinian evolution – the origin of species – takes place over eons: epigenetics prints short-term bar codes on our cells so that they remember where they’ve been and where they should be going. If they get lost, we call it cancer, obesity or diabetes. Since epigenetic changes can be induced by diet, drugs and the environment, there’s a whiff of Lamarck about the whole notion.(3) Not to worry, though: until the genome crumbles, our skin will remain skin, our bones remain bone and apes won’t turn into humans tomorrow. One trend is sure, though: nurture is gaining on nature in the old debate.

Epigenetic explanations have been extended to reach Woody Allen’s second favorite organ, the brain. If the gonads (Allen’s favorite) are the organs of classical evolution, the brain is the organ of personal and cultural evolution. Neurobiologists now believe that our brains evolve through a series of choices made by individual neurons over time. These choices are made under epigenetic control and, as in classical evolution, are forged by selective pressure with adaptive advantage.(4) Growth, learning and remembering take place in the real social network: Imagine the very different selective pressures acting on the neural networks of young women growing up in Kabul or Minneapolis.

My essays touch on the social network we call Western civilization: Antoine and Anne-Marie Lavoisier, Emerson and Margaret Fuller, Gustav and Alma Mahler; Bernard Shaw and H.G. Wells. Experimental science, I’m convinced, is a crowning achievement of that civilization, and the fact that women now function as equal partners in science is a welcome sign of its continuing vitality. Several of my chapters in this book deal with the many women of science – from the martyred Hypatia of Alexandria, the first woman scientist, to the Nobel laureates Marie Curie, Christine Nüsslein-Volhard, Elizabeth Blackburn and Carol Greider. The list speaks for itself.